Loss of blood flow to tissues and cells (ischemia) triggers a variety of damaging biochemical changes. Cooling and other interventions can slow or stop some of these changes. The progression or reduction of the damaging processes is accompanied by changes in gene activity and many gene products in the cells. These “biomarkers” of cell stress and cell death can be measured in blood and tissue samples.
By studying these biomarkers, their activity during ischemia and responses to cooling and other interventions, Suspended Animation hopes to be able to develop even more effective treatments for preventing ischemic damage.